INFLUENCE OF COMPLEX TREATMENT ON BIOCHEMICAL BLOOD PARAMETERS OF PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AND CONCOMITANT PRE-DIABETES
| Autor: | Snizhana V. Feysa, Svitlana O Rudakova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty business.industry Fatty liver Lipid metabolism General Medicine Disease Carbohydrate medicine.disease Gastroenterology chemistry Internal medicine Concomitant medicine Rosuvastatin business Dyslipidemia medicine.drug Polyunsaturated fatty acid |
| Zdroj: | Wiadomości Lekarskie. 74:986-991 |
| ISSN: | 0043-5147 |
| DOI: | 10.36740/wlek202104133 |
| Popis: | Objective The aim: Of this research is to evaluate laboratory changes in the liver blood tests, carbohydrate and lipid metabolism in NAFLD patients with concomitant pre-diabetes, and to study the feasibility of their complex treatment with the inclusion of omega-3 polyunsaturated fatty acids and essential phospholipids. Patients and methods Materials and methods: We have examined 55 patients with non-alcoholic fatty liver disease on the background of pre-diabetes aged 40 to 75 years. Modification of lifestyle was recommended to all patients as a basic treatment. In addition, the patients were prescribed essential phospholipids in 2 capsules 3 times a day and omega-3 polyunsaturated fatty acids 1000 mg per day for 28 patients (group 1) or rosuvastatin 10 mg per day for 27 persons (group 2). The effectiveness of the treatment was evaluated in 3 months, and the long-term outcomes were evaluated in 12 months. Results Results: Under the influence of the prescribed treatment, a hypolipidemic effect was observed in both groups, but a significant decline in the activity of alanine aminotransferase and aspartate aminotransferase occurred only under the influence of a combination of essential phospholipids and omega-3 polyunsaturated fatty acids. Conclusion Conclusions: Thus, the described results allow to recommend this combination of medicines to patients with non-alcoholic fatty liver disease and concomitant pre-diabetes. |
| Databáze: | OpenAIRE |
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