The control of prothrombin secretion in culture liver cells

Autor:	Mamoru Ueyama, Masahiro Tomono, Toshio Asada, Tsutomu Urayama
Rok vydání:	1988
Předmět:	medicine.medical_specialty Liver cell chemistry.chemical_element Stimulation General Medicine Calcium Biology Guinea pig Oleic acid chemistry.chemical_compound Endocrinology chemistry Internal medicine Calcium flux medicine Secretion Flux (metabolism)
Zdroj:	Blood & Vessel. 19:644-646
ISSN:	1884-2372 0386-9717
DOI:	10.2491/jjsth1970.19.644
Popis:	Vitamin K brings calcium flux as well as γ-carboxylation in liver cells. Prothrombin in creased in the medium of the guinea pig liver cell culture along with the rise of intracellulr Ca++ by vitamin K stimulation. This result indicates a secretion mechanism linked to some chemical stimulations. Pregnane-diol and oleic acid had no effect on the Ca2++ flux but suppressed the prothrombin secretion induced by vitamin K stimulation, although the inhibition mechanism unknown.
Databáze:	OpenAIRE
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