Spectroscopic studies on the complexation of some transition metals with Chloramphenicol drug
| Autor: | M.G. Abd El-Wahed, Moamen S. Refat, Samy M. El-Megharbel |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Thermogravimetric analysis
Ligand Chemistry Metal ions in aqueous solution Organic Chemistry Inorganic chemistry Infrared spectroscopy Medicinal chemistry Magnetic susceptibility Analytical Chemistry Inorganic Chemistry Metal chemistry.chemical_compound Transition metal visual_art Amide visual_art.visual_art_medium Spectroscopy |
| Zdroj: | Journal of Molecular Structure. 892:402-413 |
| ISSN: | 0022-2860 |
| DOI: | 10.1016/j.molstruc.2008.06.005 |
| Popis: | Complexes of Chloramphenicol (CHL, H 2 L) with Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) were obtained in methanolic solution at ∼pH 7.00–7.50 using NaOH. Elemental analyses are consistent with the formulas: Na 2 [M(CHL) 2 (H 2 O) 2 ]· n H 2 O where (M = Mn(II), Co(II) and Ni(II), and n = 2, 4 and 6), Na 2 [M(CHL) 2 ]· n H 2 O where (M = Zn(II), Cd(II) and Hg(II), and n = 0, 1, and 2), and [Cu(CHL) 2 ]·4H 2 O. The IR spectra of the prepared complexes indicate that, the metal coordinated via both hydroxyl groups, while the Cu(II) complex is coordinated through one of the hydroxyl groups and carbonyl of the amide group. Except for Cu 2+ all the metal ions form six membered ring complexes with Chloramphenicol. These complexes have been characterized by elemental analysis, magnetic susceptibility, molar conductance, infrared, electronic spectral and thermogravimetric (TGA/DTG) measurements. The CHL ligand as well as their complexes have been checked against some kinds of bacteria and fungi and give a significant effect. The kinetic thermodynamic parameters such as: E ∗ , Δ H ∗ , Δ S ∗ and Δ G ∗ are estimated using Coats and Redfern as well as Horowitz–Metzger equations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect