Serum Immunoglobulin Paraprotein in Patients with Chronic Lymphocytic Leukemia
| Autor: | M.D. Fatma El-Zahraa A. Rashed Mohamed Z. Abd El-Rahman, M.D. Asmaa M. Zahran Hosny B. Hamed |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
biology medicine.diagnostic_test business.industry ZAP70 Chronic lymphocytic leukemia CD38 medicine.disease Gastroenterology Monoclonal gammopathy immune system diseases hemic and lymphatic diseases Internal medicine Serum protein electrophoresis medicine biology.protein In patient medicine.symptom Antibody business Staging system |
| Zdroj: | The Medical Journal of Cairo University. 86:389-394 |
| ISSN: | 2536-9806 |
| DOI: | 10.21608/mjcu.2018.55138 |
| Popis: | Background: Chronic Lymphocytic Leukemia (CLL) is the most common chronic lympho-proliferative disorder. This study was done to explore the frequency of serum Immu-noglobulin (Ig) paraprotein in patients with CLL and its correlation with other prognostic factors as expression of CD38 and zeta-chain-associated protein kinase 70 (ZAP70) on malignant lymphocytes.Aim of Study: To study the frequency of serum immu-noglobulin paraprotein in patients with CLL and its correlation with other prognostic factors as expression of CD38 and ZAP70 on malignant lymphocytes.Patients and Methods: Clinico-hematological profiles were done to 30 CLL patients. Serum Protein Electrophoresis (SPE) and Immunofixation Electrophoresis (IFE) were per-formed to measure serum Ig paraprotein. ZAP-70 and CD 38 were tested by flow cytometry.Results: In this study CLL patients were classified accord-ing to modified Rai staging system into: Low risk 10%, intermediate risk 40% and high risk 50%. Four CLL patients (13.4%) had monoclonal gammopathy (M-band), the type of M-band in the 4 patients was IgG-Kappa. One patient (3.3%) had diffuse band (polyclonal gammopathy). ZAP-70 and CD 38 positivity were detected in 7 patients (23.3%) and 15 patients (50%), respectively. There was significant relation between presence of Ig paraprotein in CLL patients and ZAP 70 expression (p=0.034). On the other hand there was no relation between presence of M-band in CLL patients and CD38 expression nor modified Rai staging system.Conclusion: Monoclonal gammopathy was found in 13.4% of CLL patients. The detection of Ig paraprotein might be applied for the assessment of prognosis in patients with CLL. |
| Databáze: | OpenAIRE |
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