Lipid Metabolism in Non-Insulin-Dependent Diabetes Mellitus
| Autor: | Leonard Doberne, Michael S. Greenfield, Gerald M. Reaven, Hendrik J. Vreman, Mark Rosenthal |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Triglyceride business.industry Cholesterol Non insulin dependent diabetes mellitus Lipid metabolism medicine.disease chemistry.chemical_compound Endocrinology chemistry Internal medicine Diabetes mellitus Internal Medicine medicine lipids (amino acids peptides and proteins) business Glipizide medicine.drug Diabetic control Lipoprotein |
| Zdroj: | Archives of Internal Medicine. 142:1498 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1982.00340210094019 |
| Popis: | • Plasma lipid concentration and lipoprotein composition were studied before and after several months of glipizide treatment in 23 patients with non-insulin-dependent diabetes mellitus. The mean (±SEM) plasma glucose level fell 87 mg/dL, and the fall in plasma glucose concentration was correlated with a reduction in plasma triglyceride, very low-density lipoprotein triglyceride, cholesterol, and low-density lipoprotein cholesterol levels. Furthermore, there was a statistically significant increase in the plasma high-density lipoprotein cholesterol to total cholesterol ratio. Thus, improved diabetic control in patients treated with glipizide with non-insulin-dependent diabetes mellitus leads to changes in lipoprotein metabolism thought to be beneficial in terms of known cardiovascular risk factors. (Arch Intern Med1982;142:1498-1500) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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