Prognostic value of the post-operative red blood cell distribution width in patients with rectal cancer with neoadjuvant chemoradiation followed by surgery
| Autor: | Yingkun Ren, Zhiling Wang, Peijun Wang, Jianguo Xie |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Chemotherapy medicine.medical_specialty Multivariate analysis business.industry Colorectal cancer medicine.medical_treatment Biophysics Cancer Red blood cell distribution width Cell Biology Perioperative medicine.disease Biochemistry Peripheral blood Surgery 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Post operative business Molecular Biology |
| Zdroj: | Bioscience Reports. 40 |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1042/bsr20201822 |
| Popis: | Purposes: Several studies have reported that elevated red cell distribution width (RDW) is related to poor prognosis in several cancers; however, the prognostic significance of perioperative RDW in patients with rectal cancer that received neoadjuvant chemoradiation therapy (NACRT) is unclear. Methods: A total of 120 patients with rectal cancer who received NACRT followed surgery were retrospectively reviewed from Affiliated Cancer Hospital of Zhengzhou University between 2013 and 2015. Data for peripheral blood tests prior to the initiation of NACRT, before surgery and first chemotherapy after surgery were collected, respectively. The optimal cutoff values of RDW were determined by ROC analysis, respectively. The relationship between RDW and the prognosis of patients was evaluated by the Kaplan Meier method, respectively. Results: The post-operative RDWHigh patients had significantly worse 5-year overall survival (OS, P=0.001) and disease-free survival (DFS, P Conclusion: Post-operative RDW might be a useful prognostic indicator in patients with rectal cancer received neoadjuvant chemoradiation. |
| Databáze: | OpenAIRE |
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