Complete response of a hepatocellular carcinoma with complex macrovascular invasion after combined treatment with chemoembolization and immunotherapy: a case report
| Autor: | A Covas, I Tancredi, Gontran Verset, M Pezzullo, AM Bucalau |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lung business.industry medicine.medical_treatment Selective internal radiation therapy Immunotherapy Hepatology medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma Internal medicine medicine 030211 gastroenterology & hepatology Doxorubicin Radiology Vein business Complete response medicine.drug |
| Zdroj: | Acta Gastro Enterologica Belgica. 84:371-374 |
| ISSN: | 1784-3227 |
| DOI: | 10.51821/84.2.371 |
| Popis: | Hepatocellular carcinoma accounts for 90% of primary liver cancers and represents a growing health problem worldwide. We report the complex case of a 71 year-old patient diagnosed with a large hepatocellular carcinoma and presenting an extensive vascular invasion of the middle hepatic vein and the inferior caval vein ascending to the right atrium with no extrahepatic spread. Due to several comorbidities, a systemic treatment by tyrosine kinase inhibitors was contraindicated. After discussion at the multidisciplinary hepatology tumor board, he was referred for selective internal radiation therapy. Unfortunately, the work-up showed an important lung shunt not allowing radioembolization. No clear recommendations are available in this situation. The decision was made to propose a combination treatment by transarterial chemoembolization, that was performed using a new generation of radio-opaque microspheres loaded with doxorubicin, followed by immunotherapy. This allowed a complete response with a very good quality of life. |
| Databáze: | OpenAIRE |
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