New Synthetic Approach to 1-Azabicyclo[x.y.0]alkalne Skeletons from b-Enamino Diesters Derived from Meldrum's Acid

Autor:	G屍ard Lhommet, Mansour Haddad, Jean Pierre C四屍ier, Gjergj Haviari, Hamid Dhimane, Jean Claude Pommelet, Josselin Chuche
Rok vydání:	1990
Předmět:	Pharmacology chemistry.chemical_classification Bicyclic molecule Intramolecular reaction Double bond Chemistry Decarboxylation Organic Chemistry Transesterification Meldrum's acid Medicinal chemistry Analytical Chemistry chemistry.chemical_compound Moiety Stereoselectivity
Zdroj:	HETEROCYCLES. 31:1251
ISSN:	0385-5414
Popis:	Two complementary methods for the synthesis of title compounds , namely, monodecarboxylating transesterification of β-enamino esters (I) followed by intramolecular cyclization, and direct cyclization of I under flash vacuum thermolysis conditions, have been elaborated. Azabicyclic compounds were stereospecifically converted to bicyclic β-amino alcohols by means of stereocontrolled carbon-carbon double bond catalytic hydrogenation followed by ester moiety reduction
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::44831736720fa25790241e7a7b0afde1 https://doi.org/10.3987/com-90-5319 Zobrazit plný text záznamu