Influence ofNauclea latifolia. Leaf Extracts on Some Hepatic Enzymes of Rats Fed on Coconut Oil and Non-Coconut Oil Meals

Autor:	F. V. Udoh, Eyong U. Eyong, I. B. Umoh, Monday I. Akpanabiatu
Rok vydání:	2005
Předmět:	Pharmacology chemistry.chemical_classification Meal Ethanol Rubiaceae food.ingredient Nauclea biology Coconut oil Pharmaceutical Science General Medicine Pharmacognosy biology.organism_classification chemistry.chemical_compound Enzyme food Animal science Complementary and alternative medicine chemistry Oral administration Drug Discovery Botany Molecular Medicine
Zdroj:	Pharmaceutical Biology. 43:153-157
ISSN:	1744-5116 1388-0209
Popis:	This work focuses primarily on the comparative response of rat liver enzymes to oral administration of the watersoluble fraction of 95% ethanol extract of Nauclea latifolia Sm. (Rubiaceae) leaves with 10% coconut oil meal and normal rat chow fed for 8 weeks. Forty-eight mature male albino rats of the Wistar strain weighing between 200 and 230 g were divided into two experimental groups. In experiment 1, group 1 (n ¼ 6) was fed normal rat chow for 8 weeks, and groups 2, 3, and 4 (n ¼ 6) were on normal rat chow for 8 weeks before treatment with 170, 340, and 510 mg=kg body weight, respectively, of oral dose of the water-soluble fraction of the ethanol extract of N. latifolia leaves. In experiment 2, group 1 (n ¼ 6) was fed the 10% coconut oil meal as the experimental control, and groups 2, 3, and 4 (n ¼ 6) were fed the 10% coconut oil meal for 8 weeks before commencing treatment for 2 weeks with the extract of N. latifolia leaves. The effects of the N. latifolia leaf extract on some marker enzymes were analyzed. There was a significant increase ( p 0:05) in experiment 1 animals when compared with control. Increase in ALT activity was however observed in experiment 2 (p 0:05) change in c-GT activity in experiment 1, but in experiment 2 glutamyl transferase (GGT) decreased in the water-soluble fraction of the ethanol extract. N. latifolia leaf extract is capable of reducing the activity of c-GT if raised by other factors. We also concluded that feeding animals with 10% coconut oil meal predisposes them to more adverse effects by the extract of N. latifolia leaves.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4481a26120206bf1a16bd67694424b12 https://doi.org/10.1080/13880200590919492 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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