Physiologic features of hemolysis axxociated with altered cation and 2,3-diphosphoglycerate content

Autor:	Maurice M. Albala, Bertil Glader, Normand L. Fortier
Rok vydání:	1978
Předmět:	medicine.medical_specialty medicine.diagnostic_test Chemistry Immunology Hemolytic disorder Cation composition Liter Cell Biology Hematology Hematocrit medicine.disease Biochemistry Oxygen affinity Hemolysis Endocrinology Internal medicine medicine Diphosphoglycerate Whole blood
Zdroj:	Blood. 52:135-141
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v52.1.135.135
Popis:	A hemolytic disorder characterized by altered RBC cation composition (increases Na, decreases K), reduced monovalent cation content (decreased Na + K/liter RBC), and decreased levels of 2,3- diphosphoglycerate (2,3-DPG) is described. The etiology of these RBC abnormalities was not elucidated following extensive laboratory evaluation, although two important physiologic principles were manifested by this case: (1) Hemolysis was relatively well compensated (41% hematocrit) despite a significantly decreased RBC survival (51 Cr t 1/2 = 10.5 days). This effect presumably was due to reduced 2,3-DPG content (1.9 mumol/ml RBC) and the associated increase in whole blood oxygen affinity (P50 = 19.6 mm hg). (2) RBC size and water content were normal in spite of marked cation depletion. This anomaly was thought to reflect the osmotic effects of reduced polyvalent anion (2,3-DPG) content.
Databáze:	OpenAIRE
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