Dual inhibition of neutral endopeptidase and angiotensin-converting enzyme by N-phosphonomethyl and N-carboxyalkyl dipeptides
| Autor: | Stéphane De Lombaert, Yumi Sakane, Jenny Tan, R. D. Ghai, Lisa J. Stamford, Carol Berry |
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| Rok vydání: | 1994 |
| Předmět: |
biology
Stereochemistry fungi Organic Chemistry Clinical Biochemistry Pharmaceutical Science Angiotensin-converting enzyme Captopril Phenylalanine Thiorphan Biochemistry In vitro chemistry.chemical_compound chemistry Drug Discovery ACE inhibitor biology.protein medicine Molecular Medicine Potency Molecular Biology Neprilysin medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 4:2715-2720 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)80703-4 |
| Popis: | Structural modifications have been performed on the selective α-amino phosphonic acid NEP inhibitor CGS 24592, to achieve dual ACE/NEP inhibition in vitro. (S)-N-Phosphonomethyl-valyl-(S)-(4-phenyl)phenylalanine (19) is representative of a new type of phosphorus-containing ACE/NEP inhibitors, approaching the in vitro potency of the sulfhydryl ACE inhibitor captopril and the NEP inhibitor thiorphan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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