| Autor: |
A.L. Pastushenkov, V.V. Dvoryanchikov, St.-Petersburg Pharm-TRISAN, L.A. Sorokina, М.S. Kuznetsov, L.A. Glaznikov, L.G. Buynov, V.L. Pastushenkov |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Aerospace and Environmental Medicine. 55:69-75 |
| ISSN: |
0233-528X |
| Popis: |
The paper reports the results of testing efficiency of a triazinoindole derivative in an experiment with modeled acoustic injury. Animals (116 (CBA x C57BL/6) F1 hybrid female mice) were randomly distributed in 5 groups. Groups A, B and C received I/M triazinoindole at 5, 7 and 10 mg/kg/d respectively. Group D was injected with the cytoflavin (reference medicine) at 1.7 ml/7 мl/kg. Group E was a control that received injections of 2 ml of 0.9 % sodium chloride solution. Following 5 days of injections, the mice were exposed to white noise of 107 dB. Analysis of auditory evoked potentials demonstrated a dose-dependent oto-protective effect of the triazinoindole derivative. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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