| Autor: |
Michal Mekel, Moran Szwarcwort-Cohen, Ronit Almog, Michael Halberthal, Jalal Tarabeia, Halima Dabaja-Younis, Nethanel A. Horowitz, Khetam Hussein, Vardit Gepstein, Neta Petersiel, Avi Weissman, Hagar Cohen Saban, Yael Shachor-Meyouhas, Itamar Netzer, Gila Hyams |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Microbiology and Infection. 28:450.e1-450.e4 |
| ISSN: |
1198-743X |
| Popis: |
Objectives We evaluated antibody response to the BNT162B2 vaccine among healthcare workers (HCWs) to identify factors associated with decreased immunogenicity. Methods This prospective cohort study included consenting HCWs who completed a questionnaire regarding background illnesses, medications, and post vaccination allergic reactions or rash. All HCWs were tested for anti-spike antibodies (LIAISON SARS-CoV-2 S1/S2 IgG assay) one and three months after second vaccine dose. A multivariate mixed linear model was adjusted to participant's data and fit to predict antibody levels after second BNT162B2 vaccine dose, based on antibody levels at 1 month and the slope between 3 and 1 month. Multivariate analyses identified factors associated with lower antibody levels. Results A total of 1,506 HCWs were tested for SARS-CoV-2 antibodies. Older age was associated with lower mean antibody levels (-1.22 AU/ml, p Conclusions Most HCWs had measurable antibodies at 3 months. Risk factors for lower antibody levels were older age, male sex, underlying condition, and immunosuppressive treatment. These factors may be considered when planning booster doses during vaccine shortage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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