Kadar heat shock protein 70 (HSP 70) yang tinggi pada serum ibu sebagai faktor risiko persalinan preterm
| Autor: | Tjokorda G. A. Suwardewa, Ketut Surya Negara, Anak Agung Ngurah Anantasika, I Wayan Artana Putra, I Gde Sastra Winata, Piere Emanuel Yoltuwu |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Intisari Sains Medis. 13:181-184 |
| ISSN: | 2503-3638 2089-9084 |
| DOI: | 10.15562/ism.v13i1.1329 |
| Popis: | Introduction: Preterm birth defined as parturition that occurs less than 37 completed weeks of gestation is still being a big problem in obstetrics, especially in perinatology. Preterm delivery is one of the most common causes of neonatal morbidity and mortality. This study examined serum HSP 70 levels as a risk factor for preterm delivery.Method: The research design was analytic with a case-control method at Sanglah Hospital from February to June 2021. The samples were divided into two groups which are in the case group was 30 samples and the control group was 30 samples. In both groups, HSP 70 levels were collected by taking 5cc of blood sample from cubital vein. Furthermore, the examination was carried out using the enzyme-link immunosorbent assay (ELISA) method at Biomedik Terpadu Laboratory service.Result: Based on the data on the characteristics of the subjects, respectively maternal age, gestational age, BMI, and parity there was no significant differences between two group. Serum HSP levels were significantly different between the two groups with OR 4.030 (95%CI: 1,372-11,84; p-value 0.01). The cut-off value for serum HSP 70 levels was 12.85 ng/ml, with a sensitivity of 70%, specificity of 63.3%, and an area under the curve (AUC) value of 0.807 (95% CI 0.697 – 0.916, p-value |
| Databáze: | OpenAIRE |
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