Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours
| Autor: | Lone Helboe, Stephen L. Atkin, Karen Bedford, Lindsay W. Turnbull, I Richmond, Glen H. Hall |
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| Rok vydání: | 2005 |
| Předmět: |
endocrine system
Cancer Research medicine.medical_specialty Oncogene Somatostatin receptor Angiogenesis Biology medicine.disease Neovascularization Vascular endothelial growth factor Ovarian tumor chemistry.chemical_compound Endocrinology Oncology chemistry Internal medicine Neuropilin 1 cardiovascular system medicine Cancer research medicine.symptom Ovarian cancer |
| Zdroj: | International Journal of Oncology. |
| ISSN: | 1791-2423 1019-6439 |
| DOI: | 10.3892/ijo.27.5.1283 |
| Popis: | Vascular endothelial growth factor (VEGF), is an angiogenic growth factor, expressed more highly in malignant than benign ovarian tumours. Neuropilin-1, which can act as a VEGF receptor has been shown to be associated with tumour angiogenesis in some cancer systems. Somatostatin (SST), a potentially anti-angiogenic factor, acts via somatostatin receptors that are expressed in ovarian cancer. We used immunohistochemistry to demonstrate expression of Neuropilin-1 in 63 malignant and 35 benign ovarian tumours and compared it to VEGF, Fit, Flk, SST expression and tumour microvessel density (MVD). Neuropilin-1 was expressed in 34/63 malignant and 22/35 benign lesions. VEGF, Flt, Flk and SST were expressed more highly in the epithelium of malignant and the vessels of benign lesions. VEGF expression correlated with SST expression in the epithelium (p |
| Databáze: | OpenAIRE |
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