Synthesis of 1-aroylmethyl-and 1-aryloxymethyl-3,4-dihydroisoquinolines and their effects on blood clotting

Autor:	B. Ya. Syropyatov, E. S. Limanskii, N. N. Polygalova, N. G. Ismailova, A. G. Mikhailovksii, M. I. Vakhrin
Rok vydání:	2008
Předmět:	Pharmacology Acylation chemistry.chemical_compound Anticoagulant effect chemistry Blood clotting Active compound Drug Discovery Pharmacology toxicology Organic chemistry Phenols Catalysis
Zdroj:	Pharmaceutical Chemistry Journal. 42:68-71
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-008-0062-5
Popis:	Acylation of a number of tertiary enamines with aroylchlorides was used to synthesize 1-aroylmethyl-3,4-dihydroisoquinolines. Reaction of 1-chloromethyl-3,3-dimethyl-3,4-dihydroisoquinoline with phenols with interphase catalysis was also used to make 1-aryloxymethyl-3,4-dihydroisoquinoline derivatives. 1-Aroylmethylisoquinolines characteristically had a hemostatic effect, while 1-aryloxymethyl-3,4-dihydroisoquinolines had an anticoagulant effect. The most active compound increased blood clotting by 17.7%.
Databáze:	OpenAIRE
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