| Autor: |
Paula Martínez-Román, Isabel Cortegano, Daniel Valle Millares, Celia Crespo-Bermejo, Norma Rallón, José Miguel Benito, Violeta Lara-Aguilar, Sonia Arca-Lafuente, Luz Martín-Carbonero, Lourdes Domínguez-Domínguez, Pablo Ryan, Ignacio de los Santos, Mayte Coiras, Claudia Palladino, María Luisa Gaspar, Amanda Fernández-Rodríguez, Verónica Briz |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Previously, we identified a stabilization of the HIV reservoir size in HIV + monoinfected and HIV+/HCV + coinfected patients who eliminated HCV with DAAs as well as a decrease in HIV reservoir size in HIV+/HCV- spontaneously clearers. However, variations in the distribution of memory CD4 + T cell subpopulations in coinfected patients after HCV clearance remains unclear. To analyze the expression pattern of T cell maturation (CD45RA and CD27) and senescence (CD28 and CD57) markers by flow cytometry in those patients. Longitudinal study (52 weeks follow-up) of 49 HIV+/HCV+, 38 HIV+/HCV- and 59 HIV + subjects, all of them aviremic. A generalized increase in expression of CD28 was observed for CD8 + and in CD4 + CD27 + cells. The proportion of both CD4 + TEM TH1 and TH2 cells decreased significantly in HIV+/HCV- while remained stable in HIV + and HIV+/HCV + individuals. The general decline in cell senescence of cytotoxic lymphocytes may be due to reduced antigenic stimulation of HIV-specific and HCV-specific lymphocytes. The dynamic of HIV viral reservoir in HIV+/HCV- patients matches the dynamic of CD4 + cells with a TH1 phenotype, which could mean a decrease in the number of circulating TFH1 lymphocytes after an improvement in generalized inflammation state. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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