Influence of Progesterone on Experimental Tuberculosis in Male Guinea Pigs
| Autor: | Herbert R. Morgan, Meridian R. Greene |
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| Rok vydání: | 1938 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 38:656-658 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-38-9972 |
| Popis: | As the condition of tuberculous patients appears to improve during the early months of pregnancy, we were interested in noting what influence the hormone, progesterone, might have on experimental tuberculosis.Steinbach and Klein1 found that pregnant mare serum, Antuitrin-S and Follutein to a less degree, retarded tuberculosis in rabbits and guinea pigs. Since the latter two agents stimulate the ovaries to luteinization, it seemed not unlikely that the effect on tuberculosis might be due to a hormone from the corpus luteum, which develops and persists during pregnancy.Male guinea pigs were used to eliminate fluctuations in secretion of hormones from the ovaries that would occur in the female. Animals used had an initial range of weights from 370-470 g and were negative to tuberculin. Twenty were inoculated subcutaneously with 1 mg of the C3 strain of bovine tubercle bacilli. On the same day, 1/2 unit of progesterone∗ was given to each of 10 of these animals and to a non-infected one by the subcutaneous rou... |
| Databáze: | OpenAIRE |
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