SLiMs in intrinsically disordered protein regions regulate the cell cycle dynamics of ORC1-CDC6 interaction and pre-replicative complex assembly
| Autor: | Mart Loog, Ilona Faustova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
biology Protein subunit Cell Biology Computational biology Cell cycle Pre-replicative complex assembly 03 medical and health sciences 0302 clinical medicine Licensing factor Cyclin-dependent kinase biology.protein Origin recognition complex Short linear motif ORC1 Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Molecular Cell. 81:1861-1862 |
| ISSN: | 1097-2765 |
| DOI: | 10.1016/j.molcel.2021.04.016 |
| Popis: | Hossain et al. (2021) show that human origin recognition complex subunit ORC1 and licensing factor CDC6 interact when the pre-replicative complex forms in G1. Short linear motifs (SLiMs) in intrinsically disordered regions (IDRs) mediate this interaction and its regulation by CDKs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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