An Efficient and Chemoselective Deprotection of Aryltert-Butyldimethylsilyl (TBDMS) Ethers by NaCN

Autor: Guoliang Chen, Xue-jun Qiao, Fang Wuhong, Xiao Hou, Xue-fei Bao
Rok vydání: 2015
Předmět:
Zdroj: Journal of the Brazilian Chemical Society.
ISSN: 0103-5053
DOI: 10.5935/0103-5053.20150342
Popis: Phenolic tert-butyldimethylsilyl (TBDMS) ethers can be deprotected to yield phenols in excellent yield using sodium cyanide (NaCN) as catalyst in ethanol. The deprotectation of various phenolic TBDMS ethers were found to be very convenient, fast, high yielding and chemoselective.
Databáze: OpenAIRE