4.39 Hybrid Magnetic Nanoparticles for Targeted Delivery
| Autor: | Romain Epherre, Stéphane Mornet, Etienne Duguet, Graziella Goglio |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Modern medicine
Biodistribution Materials science medicine.diagnostic_test Tumor cells Nanotechnology Magnetic resonance imaging 02 engineering and technology equipment and supplies 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Magnetic hyperthermia Drug delivery medicine Magnetic nanoparticles 0210 nano-technology human activities Biomedical engineering |
| Popis: | Magnetic nanoparticles (MNPs) have attracted attention in modern medicine and pharmacology because of their potential usefulness as contrast agents for magnetic resonance imaging (MRI), as colloidal mediators for cancer magnetic hyperthermia or as active constituents of drug delivery platforms. This review examines these in vivo applications through an understanding of the involved problems and the current and future possibilities for resolving them. A special emphasis is made on MNP requirements from a physical viewpoint (e.g., relaxivity for MRI, specific absorption rate for hyperthermia, magnetic guidance), the factors affecting their biodistribution after intravenous injection (e.g., size, colloidal stability, surface hydrophobic/hydrophilic balance) and the solutions envisaged for enhancing their half-life in the blood compartment and targeting tumor cells. |
| Databáze: | OpenAIRE |
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