Immune Status Creative Analysis in Patients after Coronary Artery Bypass Surgery (CABS) With the use of Cardiopulmonary Bypass (CPB) Machine

Autor:	Pronko Kn, G.P. Plotnikov, Revishvili A. Sh., A N Korostelev, A L Sadiykov, M N Kozlova, V S Demidova, V V Kazennov, N. S. Shishkina, Andrey M Zemskov, Vladimir M Zemskov, V A Popov, A A Barsukov
Rok vydání:	2020
Předmět:	Immune status Coronary artery bypass surgery medicine.medical_specialty law business.industry Internal medicine Cardiopulmonary bypass Cardiology medicine In patient business law.invention
Zdroj:	Global Journal of Medical Research. :19-32
ISSN:	2249-4618 0975-5888
DOI:	10.34257/gjmrivol20is1pg19
Popis:	An analysis of the immune status in 53 patients that underwent coronary artery bypass grafting under cardiopulmonary bypass was carried out in the preoperative period and on day 1 and 7 after the surgical intervention. Significant changes in innate and adaptive immunity were revealed. In the first case, they were expressed as an inflammatory process developed throughout the postoperative period; it was confirmed with an increase in leukocytes, total and stab granulocytes, monocytes, oxidative stress of phagocytes, CD64+ and CD40+ granulocytes, endogenous intoxication with the developed significant deficiency in CD4+ monocytes, and regulatory NK cells; while immediately after the surgery, it was confirmed by IgG and IgM levels.Some changes in adaptive immunity manifested through its activation, confirmed by an increased CD4+, CD11b+, HLA-DR+, and CD4+CD25+lymphocyte content, together with a deficiency noted in total lymphocytes and CD8+ lymphocytes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::440d72c33f66f1e4e9cd53f145d2cb8c https://doi.org/10.34257/gjmrivol20is1pg19 Zobrazit plný text záznamu