Abstract 4210: HP and EBVaGC in Peruvian patients
| Autor: | Eduardo Payet Meza, Iván Chávez Passiuri, Daniel Valdivia Leonardo, Joselyn R. Sanchez Sifuentes, Omar Mejía Dionisio, Valeria Villegas Bernaola, Carolina Belmar Lopez, Manuel A. Chumpitaz La Rosa Sanchez, Miluska Castillo Garcia, Jais Nieves Prado, Luis F. Barreda Bolaños, Luis A. Bernabé Monsalve, Carlos Castaneda Altamirano |
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| Rok vydání: | 2018 |
| Předmět: |
Cancer Research
medicine.medical_specialty education.field_of_study biology business.industry Population Prevalence Cancer Helicobacter pylori biology.organism_classification medicine.disease Gastroenterology Virus Real-time polymerase chain reaction Oncology Internal medicine Medicine Stage (cooking) business education Viral load |
| Zdroj: | Cancer Research. 78:4210-4210 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/1538-7445.am2018-4210 |
| Popis: | BACKGROUND: Gastric cancer (GC) is the second most common cancer and first leading cause of cancer-related deaths in Peru. Infection by Helicobacter pylori (HP) and Epstein-Barr virus (EBV) are accepted carcinogenic and infection is widely spread in the Peruvian population. The aims of this study were to evaluate HP and EBV-associated GC (EBVaCG), to assess the prevalence rate and to define the characteristics of Peruvian patients. METHODS: GC samples were prospectively collected from patients who underwent gastroscopy or surgical resection with no preoperative treatment at INEN between 2015 and 2017. Tumor tissue (T), proximal healthy tissue (P) and distal healthy tissue (D) samples were assessed for HP and EBV by quantitative PCR (qPCR) using specific primers. HP and EBV status were analyzed along with clinicopathologic parameters of the tumor. Kaplan-Meier estimation curves overall survival (OS) was applied. Comparison between qPCR detection and current standard methods of detection was also performed. All tests were two sided, and a p≤0.05 was considered statistically significant. RESULTS: A total of 150 patients were studied with a mean age 65 years and predominance of males (51.3%). Intestinal-mixed histological subtype rate was 72.5% in cases. Most frequent clinical stage was III-IV (74.6%). HP+ patients were determinate with at least one ureA/hspA gene result and EBV+ patients were divided in high viral load (>100copy/μl) and low viral load ( Citation Format: Carolina Belmar López, Miluska Castillo Garcia, Carlos A. Castañeda Altamirano, Luis F. Barreda Bolaños, Daniel Valdivia Leonardo, Eduardo Payet Meza, Valeria Villegas Bernaola, Jais Nieves Prado, Joselyn R. Sanchez Sifuentes, Luis A. Bernabé Monsalve, Manuel A. Chumpitaz La Rosa Sanchez, Omar Mejía Dionisio, Ivan Chavez Passiuri. HP and EBVaGC in Peruvian patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4210. |
| Databáze: | OpenAIRE |
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