Fabrication of Pure Electrospun Materials from Hyaluronic Acid
| Autor: | Ewelina Pabjańczyk-Wlazło, Izabella Krucińska, Maciej Boguń, Agnieszka Komisarczyk, Beata Kolesinska, Michał Chrzanowski, Grzegorz Szparaga, Agata Chaberska |
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| Rok vydání: | 2017 |
| Předmět: |
Biocompatible polymers
Materials science Fabrication Materials Science (miscellaneous) Natural polymers Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Industrial and Manufacturing Engineering Electrospinning 0104 chemical sciences chemistry.chemical_compound chemistry Hyaluronic acid Business and International Management 0210 nano-technology General Environmental Science |
| Zdroj: | Fibres and Textiles in Eastern Europe. 25:45-52 |
| ISSN: | 1230-3666 |
| Popis: | The aim of the research was to develop optimal conditions for manufacturing materials based on hyaluronic acid by the electrospun method. The studies were composed of three stages: the process of selection of the optimal solvent (mixture of solvents), the molecular weight of hyaluronic acid, and the concentration of biopolymer in the spinning solution. The influence of variable parameters on the rheological properties of the spinning solutions and electrospinning trails was tested. Depending on the electrospinning regime applied, the fibers obtained were characterised by a diameter of the order of 20 to 400 nm. As a result of the development works presented, an optimal molecular weight of the polymer, its concentration and system of solvents were determined, together with process parameters, ensuring a stable electrospinning process and relatively homogeneous nanofibers. Additionally studies on the residues of solvents used during electrosun formation were done and parameters of drying of the final materials were examined. This approach (verification of the presence oforganic solvent residue in the nanofibrous formed) is important for the suitability of nanofibres as scaffolds for regenerative medicine. This study provides an opportunity for the understanding and identification of process parameters, allowing for predictable manufacturing nanofibers based on natural biopolymers, which makes it tremendously beneficial in terms of customisation. |
| Databáze: | OpenAIRE |
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