The Rho(D) Specificity of a Polysaccharide Isolated from a Species of Pseudomonas

Autor:	Nancy J. Bigley, Matthew C. Dodd, Chester I. Randles, Virginia B. Geyer, Alvin G. Lazen
Rok vydání:	1963
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 90:526-531
ISSN:	1550-6606 0022-1767
Popis:	Summary A polysaccharide from an unidentified species of Pseudomonas (PsP) has been shown to possess antigenic specificity similar to the Rho(D) antigen of human red cells. The following findings revealed this specificity: a) PsP inhibited anti-D agglutinins; b) anti-PsP rabbit sera contained both saline agglutinins and incomplete antibodies specific only for cells containing D antigen; c) D-positive cells absorbed specific agglutinins from anti-PsP sera; d) anti-D serum blocked agglutination of D cells by anti-PsP serum. Agglutination of D cells by anti-PsP rabbit serum was inhibited by N-acetylneuraminic acid (NANA) containing substances different from those previously shown to inhibit D cell agglutination by specific Rh antiserum. It was concluded that the antigenic similarity is not due to NANA but to some structure or linkage resembling it.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43ecd72b37ec9dae5327a4f4c1e29678 https://doi.org/10.4049/jimmunol.90.4.526 Zobrazit plný text záznamu