Local and systemic IgA and IgG responses of chicks to avian reoviruses: Effects of age of chick, route of infection and virus strain

Autor: G. Mukiibi-Muka, R. C. Jones
Rok vydání: 1999
Předmět:
Zdroj: Avian Pathology. 28:54-60
ISSN: 1465-3338
0307-9457
DOI: 10.1080/03079459995046
Popis: The effects of age at infection, route of infection and strain of virus on reovirus-specific IgA and IgG responses of chickens were investigated using anti-IgA and-IgG monoclonal antibodies. Three groups of SPF chickens were infected with a trypsin-resistant avian reovirus (strain R2) at 1 day old (DO), 7 days old, or 3 weeks old by oral or subcutaneous routes. Virus titres in the gut declined with increasing age of chick at infection. IgA was not detected in the intestinal contents of chicks infected at DO. Those infected orally at 7 days and 3 weeks old showed a substantial rise in intestinal IgA. In the subcutaneously-infected chicks, only those infected at 3 weeks old showed an intestinal IgA response. There were very similar reovirus-specific IgG responses in the sera of the orally and subcutaneously infected chicks, in all age-groups. In a second experiment a trypsin-sensitive avian reovirus (TR1) was used to infect DO and 7-day old chicks by oral and subcutaneous routes. No intestinal replication w...
Databáze: OpenAIRE
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