Cystatins: Cysteine proteases regulation and impairments in tumors and inflammation diseases
| Autor: | Tatyana A. Korolenko, I. Yu. Bravve, T. G. Filatova, M. S. Cherkanova, T. A. Khalikova |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Proteases Clinical Biochemistry Inflammation Urine Biology urologic and male genital diseases medicine.disease Biochemistry Cysteine protease female genital diseases and pregnancy complications Lymphoma Endocrinology Cystatin C Internal medicine Immunology medicine Extracellular biology.protein Molecular Medicine medicine.symptom reproductive and urinary physiology Cysteine |
| Zdroj: | Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 2:293-297 |
| ISSN: | 1990-7516 1990-7508 |
| Popis: | Cystatin C belongs to the most widespread group of endogenous extracellular cysteine protease inhibitors; its biological functions are investigated now. Using the ELISA method we have demonstrated that the highest cystatin C concentration is registered in human cerebrospinal fluid; significantly lower cystatin C lever is detected in human urine. In healthy individuals of young age serum cystatin C concentration is lower than in elder persons (of 50–65 years old). In patients with hemoblastoses (lymphoma, lymphogranulomatosis) increased serum cystatin C concentration was normalized after effective antitumor therapy. This suggests that serum cystatin C concentration can be used as one of the prognostic criteria in patients with several types of hemoblastoses. |
| Databáze: | OpenAIRE |
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