Preclinical evaluation of repeated dose toxicity and anxiolytic activity of monoterpene R - (+) limonene via inhalation
| Autor: | Margareth de Fátima Formiga Melo Diniz, Guilherme Eduardo Nunes Dias, Reinaldo Nóbrega de Almeida, Mateus Feitosa Alves, Josué do Amaral Ramalho, Sócrates Golzio dos Santos, Kardilândia Mendes de Oliveira, Andressa Brito Lira, Vanessa Feitosa Alves |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology Elevated plus maze Limonene Inhalation Chemistry medicine.drug_class Monoterpene Pharmaceutical Science Anxiolytic (R)-(+)-limonene 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Toxicity medicine Bone marrow 030217 neurology & neurosurgery |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 10:598-603 |
| ISSN: | 1996-0816 |
| DOI: | 10.5897/ajpp2016.4606 |
| Popis: | R - (+) - limonene is a monoterpene found in several plant species. Studies have shown that plants that have this compound has anxiolytic activity. This study aimed to investigate the anxiolytic and toxicological activity in rats after inhalation of R - (+) - limonene for 30 min. For the anxiety tests using Elevated Plus Maze (EPM), concentrations of 1.0, 2.5 and 5.0% were determined. From the results, it was observed that the last concentration had achieved anxiolytic effect. Based on these results, it was found by biochemical and hematological tests, toxicity of 5% concentration in the period of 30 days with minor significant changes. In the hematological parameters, MCV, MCH and MCHC values were significant when compared to the control group, but were within the normal range when compared to values found ​​in literature. In the biochemical parameters, changes occurred in AST and LDH levels. Elevated LDH levels can cause destruction of erythrocyte precursor cells in the bone marrow. In turn, AST may be associated to small changes in the liver. Therefore, the results demonstrated an anxiolytic activity with low toxicity at dose of 5% R - (+) - limonene via inhalation for 30 min. Key words: R-(+)-limonene, inhalation, biochemical, hematological, anxiolytic, toxicity. |
| Databáze: | OpenAIRE |
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