Doses of primaquine administered to children with Plasmodium vivax according to an age-based dose regimen
| Autor: | Amanda Gabryelle Nunes Cardoso Mello, Luann Wendel Pereira de Sena, Tamyris Regina Matos Lopes, José Luiz Fernandes Vieira, Robert J. Commons, Michelle Valeria Dias Ferreira Vieira |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty Primaquine media_common.quotation_subject 030106 microbiology 030231 tropical medicine Plasmodium vivax Microbiology Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Dosing media_common biology Plasma samples business.industry Public Health Environmental and Occupational Health General Medicine medicine.disease biology.organism_classification Regimen Infectious Diseases Total dose Parasitology business Malaria medicine.drug |
| Zdroj: | Pathogens and Global Health. 114:388-392 |
| ISSN: | 2047-7732 2047-7724 |
| DOI: | 10.1080/20477724.2020.1799166 |
| Popis: | Primaquine is still the first-line drug to eliminate hypnozoites of Plasmodium vivax. The therapeutic efficacy is related to the total dose administered. In several endemic areas, the drug is administered for children in an age-based regimen, which can lead to inadequate exposure, increasing the rates of recurrence of the infection. The present study aims to describe the mg/kg total dose of primaquine administered to children for treatment for vivax malaria when an age-based regimen is used and to measure the plasma concentrations of primaquine and carboxyprimaquine. A total of 85 children were included in the study. The total dose of primaquine administered based on mg/kg had a median value of 3.22 mg/kg. The percentage of patients with a total dose below the required dose of 3.5 mg/kg was 55.75%. The median primaquine maximum concentration was 94 ng/ml. For carboxy-primaquine, the median maximum concentration was 375 ng/ml. The results suggest that age-based dosing regimens likely lead to substantial under-dosing of primaquine, which is evident in the youngest children and is reflected in decreased levels of primaquine and carboxy-primaquine in plasma samples 13. |
| Databáze: | OpenAIRE |
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