BK virus nephropathy in renal transplant recipients

Autor:	Jagadish Jamboti
Rok vydání:	2016
Předmět:	medicine.medical_specialty Tumor Virus Infections business.industry medicine.medical_treatment Urinary system 030232 urology & nephrology Urology Immunosuppression General Medicine 030230 surgery Decoy cells medicine.disease medicine.disease_cause Asymptomatic BK virus 03 medical and health sciences 0302 clinical medicine Nephrology Immunology medicine medicine.symptom business Polyomavirus Infections Kidney transplantation
Zdroj:	Nephrology. 21:647-654
ISSN:	1320-5358
DOI:	10.1111/nep.12728
Popis:	BK virus nephropathy (BKVN) occurs in up to 10% of renal transplant recipients and can result in graft loss. The reactivation of BK virus in renal transplant recipients is largely asymptomatic, and routine surveillance especially in the first 12-24 months after transplant is necessary for early recognition and intervention. Reduced immunosuppression and anti-viral treatment in the early stages may be effective in stopping BK virus replication. Urinary decoy cells, although highly specific, lack sensitivity to diagnose BKVN. Transplant biopsy remains the gold standard to diagnose BKVN, good surrogate markers for surveillance using quantitative urinary decoy cells, urinary SV40 T immunochemical staining or polyoma virus-Haufen bodies are offered by recent studies. Advanced BKVN results in severe tubulo-interstitial damage and graft failure. Retransplantation after BKVN is associated with good outcomes. Newer treatment modalities are emerging.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43d32bb06b58db4f1bcbe9e096014c64 https://doi.org/10.1111/nep.12728 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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