Correlations between some structural and functional brain parameters in subjects with high risk of schizophrenia
| Autor: | Irina Lebedeva, P. E. Mentschikov, M. A. Omeltchenko, Kaleda Vg, T. A. Akhadov, Alexander Tomyshev, E. D. Bogdanova, N. A. Semenova |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Physiology Anterior thalamic radiation Healthy subjects Cognition Neurophysiology Audiology medicine.disease Lateralization of brain function Proton mr spectroscopy 030227 psychiatry 03 medical and health sciences Functional brain 0302 clinical medicine Schizophrenia Physiology (medical) medicine Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Human Physiology. 43:385-390 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119717040089 |
| Popis: | The study was aimed to the analysis of correlations between anatomic brain parameters and characteristics of neurophysiological and metabolic supportive mechanisms of cognitive functions in the patients with ultra-high risk of schizophrenia. The study comprised 30 young male patients and 30 age- and sexmatched mentally healthy subjects. We used the methods of diffusion-weighted tomography, single voxel proton MR spectroscopy, and oddball ERP recording. The statistically significant intergroup differences in the structural connectivity were confirmed in the anterior thalamic radiation of the left hemisphere. The diffusion abnormalities in this area were correlated with P300 latencies and the level of γ-aminobutyric acid (GABA). |
| Databáze: | OpenAIRE |
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