New Facile Synthesis of 3,4-Dihydroquinazoline-2(1H)-thiones by a Sequential Ugi-Azide/Staudinger/Aza-Wittig/Cyclization Reaction

Autor:	Qing Min, Jun Xiong, Gang Yao, Ming-Wu Ding, Zhang Jia'an, Yu Haifeng
Rok vydání:	2019
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Organic Chemistry Trimethylsilyl azide Wittig reaction Azide 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Sequence (medicine)
Zdroj:	Synlett. 30:1053-1056
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0037-1611817
Popis:	A new facile synthesis of 3,4-dihydroquinazoline-2(1H)-thiones by an Ugi-azide/Staudinger/aza-Wittig/cyclization sequence has been developed. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced tetrazoles, which, when treated with methyldiphenylphosphane and CS2, produced 3,4-dihydroquinazoline-2(1H)-thiones in good overall yields via a sequential Staudinger/aza-Wittig/cyclization reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43ba7bced3148e14bc577266054946ea https://doi.org/10.1055/s-0037-1611817 Zobrazit plný text záznamu