SYNTHESIS AND ANTICANCER EVALUATION OF NEW 1HNAPHTHO[2,3-D] IMIDAZOLE-4,9-DIONE-1,2,3 TRIAZOLE HYBRIDS

Autor:	Sasidhar Alluru, B. B. V. Sailaja, Arani Pal
Rok vydání:	2023
Předmět:	General Energy General Chemical Engineering General Chemistry General Pharmacology Toxicology and Pharmaceutics Biochemistry
Zdroj:	RASAYAN Journal of Chemistry. 16:519-526
ISSN:	0976-0083 0974-1496
DOI:	10.31788/rjc.2023.1618187
Popis:	A new series of 1H-naphtho[2,3-d]imidazole-4,9-dione-based 1,2,3-triazole hybrids (10a-10n) were synthesized by the reaction of 1-(prop-2-yn-1-yl)-1H-naphtho[2,3-d]imidazole-4,9-dione with aromatic azides via copper-catalyzed azide-alkyne cycloaddition reactions. All the synthesized compounds are screened for their in vitro anticancer activities against three cancer cell lines namely MCF-7 (breast), HeLa (cervical), and A-549 (lung) using an MTT assay. The results revealed that the compounds 10a,10c,10g, and 10k exhibited promising activity against three cancer cell lines. Especially, compound 10a displayed higher activity against all the cell lines than the standard drug, The molecular docking studies of compounds 10a-10n as EGFR targeting agents were also supported by the observed IC50 data.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43b564f4aba8a5c4a99228da4395fc39 https://doi.org/10.31788/rjc.2023.1618187 Zobrazit plný text záznamu Plný text ve formátu PDF