Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci
| Autor: | Bohumil Sak, Marta Kicia, Lenka Hlásková, Nikola Holubová, Klára Brdíčková, Dana Květoňová, Martin Kváč, Żaneta Kopacz |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
biology fungi Immunology Inflammation Histology Disease biology.organism_classification Microsporidiosis medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immune system 030220 oncology & carcinogenesis Genotype Microsporidia medicine Immunology and Allergy medicine.symptom Encephalitozoon cuniculi |
| Zdroj: | Journal of Inflammation Research. 13:583-593 |
| ISSN: | 1178-7031 |
| Popis: | Background Microsporidia of the genus Encephalitozoon are generally connected with severe infections with lethal outcome in immunodeficient hosts. In immunocompetent hosts, microsporidiosis typically establishes a balanced host-parasite relationship that produces minimal clinically overt disease. Although the alimentary tract represents one of the main primary target tissues, the mechanisms of reaching other tissues during systemic microsporidian infections remain unclear. Methods In the present study, we tested the relation between inflammation induction in immunocompetent and immunodeficient mice and the presence of spores of E. cuniculi genotype II in selected organs and in fecal specimens by using molecular and histology methods. Results We reported the positive connection between inflammation induction and the significant increase of E. cuniculi genotype II occurrence in inflammation foci in both immunocompetent BALB/c and immunodeficient severe combined immunodeficient (SCID) mice in the acute phase of infection and the re-activation of latent microsporidial infection following inflammation induction in immunocompetent mice. Conclusion The results imply possible involvement of immune cells serving as vehicles transporting E. cuniculi genotype II purposefully across the whole host body towards inflammation. With increasing number of records of infections, it is necessary to reconsider microsporidia as agents responsible for various pathologies. The elucidation of possible connection with pro-inflammatory immune responses represents an important challenge with consequences for human health and development of therapeutic strategies. |
| Databáze: | OpenAIRE |
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