929 Associations of Sleep Duration and Sleep Quality With Clinical and Histologic Features of Nonalcoholic Fatty Liver Disease (NAFLD)
| Autor: | Sweta Kochhar, Anna Mae Diehl, Ayako Suzuki, Yiping Pan, Manal F. Abdelmalek, Dawn Piercy, Cynthia D. Guy |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Hepatology business.industry Population Gastroenterology Sleep apnea Odds ratio medicine.disease Sleep in non-human animals Sleep deprivation Internal medicine Nonalcoholic fatty liver disease medicine Steatosis medicine.symptom business education Body mass index |
| Zdroj: | Gastroenterology. 146:S-931 |
| ISSN: | 0016-5085 |
| Popis: | Background & Aim: Sleep deprivation and poor quality sleep are associated with various metabolic derangements. A recent study revealed that sleep deprivation increases a risk of NAFLD. In this study, we aimed to assess whether sleep deprivation and poor quality sleep are associated with clinical and histologic features of NAFLD. Methods: We analyzed 689 adult patients with clinical diagnosis of NAFLD who were enrolled in the Duke NAFLD Clinical Database study and had liver biopsy. Information on demography, body mass index (BMI), co-morbidity, laboratory data, current sleep duration and sleep difficulty was collected at the time of biopsy. Liver biopsies were scored for steatosis, lobular inflammation, ballooning, portal inflammation, and fibrosis according to the NASH CRN scoring system. Sleep deprivation was defined as self-reported sleep less than 7 hours per day, while sleep difficulty was defined by either physician's diagnosis or answering yes to at least one of the 4 screening questions for sleep difficulty. Sleep apnea was defined by physician's diagnosis. Sleep duration, sleep difficulty and sleep apnea were then associated with BMI, serum uric acid, presence of diabetes or glucose intolerance (DM/GI), hypertension (HTN), and hyperlipidemia (HL), and histologic grades/stage of NAFLD using Chi-square tests, ANOVA, and multiple linear (logistic) regression models. Results: Average and SD of age and BMI were 48±11 years and 40±10 kg/m2 in this population. 33% were men, 83% Caucasian. 82% had histologic diagnosis of NAFLD while the rest had minimal histologic findings. 22% had advanced fibrosis. Sleep deprivation, sleep difficulty, and sleep apnea were noted in 35.5%, 67%, and 41% of the population. After adjusting for age, gender, and other sleep conditions, sleep deprivation was associated with a higher serum uric acid (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|