Famotidine Pharmacokinetics in Patients Undergoing Cardiac Surgery

Autor:	Gregory E. Scott, Claudine M. Majcher, David W. Amory, Bertil K.J. Wagner, Louis T. Di Fazio, Alan J. Spotnitz
Rok vydání:	1994
Předmět:	Volume of distribution medicine.medical_specialty business.industry General Medicine Surgery law.invention Cardiac surgery Famotidine Ranitidine Pharmacotherapy Pharmacokinetics law Anesthesia Cardiopulmonary bypass Medicine Pharmacology (medical) Cimetidine business medicine.drug
Zdroj:	Drug Investigation. 8:271-277
ISSN:	1179-1918 0114-2402
DOI:	10.1007/bf03257439
Popis:	In order to study the pharmacokinetics of famotidine in cardiac surgery patients, we administered famotidine 20mg by intravenous injection at the beginning of surgery and 12 hours after surgery in 8 patients undergoing elective cardiac surgery with cardiopulmonary bypass. Total body clearance, volume of distribution, and elimination half-life were calculated using noncompartmental analysis and compared with published normal parameters (control) using a 2-tailed, 1-sample t-test. Intra- and postoperative clearances were 2.93 ± 1.06 and 3.18 ± 1.06 ml/min/kg, respectively, which were more than 50% less than the control value (6.07 ml/min/kg; p 0.08). Intra- and postoperative half-lives were 4.52 ± 2.21 hours and 4.27 ± 1.58 hours, respectively, which were more than 50% longer than control (2.92 hours; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::439aec1b401f3dec70da5d13e56c3d4c https://doi.org/10.1007/bf03257439 Zobrazit plný text záznamu Full text from SpringerLink