A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

Autor:	Xing-Yu Gong, Qing-Yan Wu, Feng Liu, Gui-Zhen Ao, Wei-Guo Shen
Rok vydání:	2019
Předmět:	chemistry.chemical_compound Trifluoromethyl chemistry 010405 organic chemistry Reagent Environmental Chemistry Organic chemistry 010402 general chemistry 01 natural sciences Pollution Environmentally friendly 0104 chemical sciences
Zdroj:	Green Chemistry. 21:2983-2987
ISSN:	1463-9270 1463-9262
DOI:	10.1039/c9gc00886a
Popis:	A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of β-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43980a8d53aa672c3ebe441bd77bfa90 https://doi.org/10.1039/c9gc00886a Zobrazit plný text záznamu