Influence of the brain ischemia-reperfusion on the condition of the Bcl-2-dependent antiapoptotic mechanisms in hippocampus of rats with diabetes mellitus
| Autor: | T. M. Boychuk, O. M. Nika |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
business.industry musculoskeletal neural and ocular physiology Ischemia Hippocampal formation medicine.disease Endocrinology nervous system Cerebral blood flow Diabetes mellitus Internal medicine medicine General Earth and Planetary Sciences Hippocampus (mythology) business General Environmental Science |
| Zdroj: | Bukovinian Medical Herald. 20:25-29 |
| ISSN: | 2413-0737 1684-7903 |
| DOI: | 10.24061/2413-0737.xx.4.80.2016.185 |
| Popis: | In the animals without diabetes mellitus (DM), after 20 min ischemia/1 hour reperfusion, the activity of Bcl-2 antiapoptotic mechanisms increases in the hippocampal fields CA1, CA2, CA4, and reduces – in the field CA3. On the 12th day of the postischemic period, antiapoptotic activity in fields CA1 and CA4 returns to the level of activity in animals of the control group; in field CA2 it decreases compared to the controls; and, in field CA3 – depression of the antiapoptotic activity becomes deeper. The four-month DM activates Bcl-2 antiapoptotic mechanisms in fields CA3 and CA; suppresses them in the CA1 field and does not affect them – in field CA4. In rats with four-month diabetes, in early postischemic period, the activity of Bcl-2 antiapoptotic processes increases in fields CA1 and CA4, and reduces – in fields CA2 and CA3. On the 12th day of ischemia-reperfusion period in rats with diabetes, the Bcl-2 antiapoptotic activity returns to level of activity in diabetic rats without disturbing the cerebral blood flow in field CA1; decreases – in the CA4, and undergoes even greater depression than in the early period, in fields CA2 and CA3. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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