B(C6F5)3-catalyzed synthesis of coumarins via Pechmann condensation under solvent-free conditions

Autor:	S. Prakash Rao, Santosh Kumar Prajapti
Rok vydání:	2021
Předmět:	Tris Reaction conditions Solvent free 010405 organic chemistry General Chemistry Borane 010402 general chemistry Coumarin 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Phenols Pechmann condensation
Zdroj:	Monatshefte für Chemie - Chemical Monthly. 152:469-473
ISSN:	1434-4475 0026-9247
DOI:	10.1007/s00706-021-02747-1
Popis:	Tris(pentafluorophenyl)borane [B(C6F5)3] catalyzed simple, efficient and environmentally benign protocol has been developed for the Pechmann condensation using variety of phenols and β-ketoesters under solvent-free conditions to afford coumarin derivatives. The present protocol displayed significant advantages such as low catalyst loading, short reaction time, mild reaction conditions, low toxicity, easy work-up, high yields, and compatibility with other functional groups. In addition, it is a convenient, clean, and fast alternative approach for synthesizing variety of coumarin derivatives. Moreover, the applicability of this method towards large-scale synthesis demonstrated its suitability for the industrial application.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4391b5924804157ae1c24fe0ec14b2f1 https://doi.org/10.1007/s00706-021-02747-1 Zobrazit plný text záznamu Full text from SpringerLink