Safety and clinical effects of topical histatin gels in humans with experimental gingivitis

Autor:	Virginia Braman, Ray C. Williams, D. M. Simpson, David W. Paquette, Phillip M. Friden
Rok vydání:	2002
Předmět:	education.field_of_study medicine.medical_specialty Saliva business.industry Bleeding on probing Population Dentistry Placebo Oral hygiene Gastroenterology Clinical trial Gingivitis Internal medicine medicine Periodontics medicine.symptom business education Adverse effect
Zdroj:	Journal of Clinical Periodontology. 29:1051-1058
ISSN:	0303-6979
DOI:	10.1034/j.1600-051x.2002.291201.x
Popis:	Background: Our research group has recently reported that exogenously applied histatins can inhibit plaque accumulation and gingival inflammation in a preclinical canine model (Paquette et al. 1997). Objectives: The aims of the present double-blinded, randomized, controlled clinical trial were to evaluate the safety and toxicity of three histatin (P-113) concentrations in gel formulations, and to assess potential clinical benefit on the development of gingivitis (partial mouth design). Material and methods: One hundred and six healthy subjects were recruited and brought to optimal gingival health (GI
Databáze:	OpenAIRE
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