Management of Ocular Human herpesvirus 1 Infection in a White-faced Saki Monkey (Pithecia pithecia)
| Autor: | Elizabeth A Adkins, Kendra L. Bauer, Steven J Sarro, April L. Childress, James C. Steeil, James F. X. Wellehan, Kenton L Kerns, Kali A. Holder |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Anisocoria General Veterinary biology business.industry Viral encephalitis Enucleation medicine.disease biology.organism_classification Dermatology eye diseases General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology Saki monkey biology.animal medicine Coinfection Lymphocryptovirus Histopathology Primate medicine.symptom business |
| Zdroj: | Comparative Medicine. 68:319-323 |
| ISSN: | 1532-0820 |
| DOI: | 10.30802/aalas-cm-17-000119 |
| Popis: | A 20-y-old male intact white-faced saki monkey (Pithecia pithecia) presented with an acute ocular disease of the right eye. Clinical signs included periocular swelling, conjunctivitis, and anisocoria with a miotic right pupil. Conjunctival swabs were positive for Human herpesvirus 1 (HHV1) according to PCR amplification with sequencing. Initial clinical signs resolved with supportive treatment, and the animal was managed chronically by using acyclovir (5 mg/kg PO twice daily) during flare-ups. After more than 2 y, the progression of clinical disease led to enucleation of the right eye. At 2 mo after surgery, acute presentation of severe neurologic signs, including ataxia and blindness, resulted in euthanasia. Histopathology, PCR analysis, and sequencing results were consistent with viral encephalitis due to HHV1; coinfection with Pithecia pithecia lymphocryptovirus 1 was identified. This report describes the first case of managed HHV1 infection in a platyrrhine primate and the first case of HHV1 in a white-faced saki monkey that was not rapidly fatal. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|