Monocyte suppression of antigen-specific lymphocyte responses in diffuse cutaneous leishmaniasis patients from the Dominican Republic

Autor:	E A Petersen, F A Neva, A Barral, R Correa-Coronas, H Bogaert-Diaz, D Martinez, F E Ward
Rok vydání:	1984
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 132:2603-2606
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.132.5.2603
Popis:	Patients from the Dominican Republic with diffuse cutaneous leishmaniasis showed in vivo and in vitro anergy to leishmanial antigen. Relatives of these DCL patients living in the same endemic area frequently showed skin test and lymphocyte reactivity to leishmanial antigens. This further supports the concept of specific anergy in patients with diffuse cutaneous leishmaniasis. Adherent suppressor cells modulate the antigen-specific lymphocyte proliferative response. Suppressor cells could also be isolated by Percoll gradient centrifugation. Co-culturing of lymphocytes and monocytes from HLA-identical leishmanin responders and nonresponders also identified the suppressor cell as a monocyte. In one patient, this suppression disappeared when clinical cure had been accomplished.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4382589262202e2b85b41bd3bb9b8a74 https://doi.org/10.4049/jimmunol.132.5.2603 Zobrazit plný text záznamu