Bone Marrow Involvement by More Than One Entity of Hematolymphoid Neoplasm
| Autor: | Yue Zhao, Endi Wang, Anand S. Lagoo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test business.industry Chronic lymphocytic leukemia Large granular lymphocytic leukemia Plasma cell neoplasm medicine.disease Myeloid Neoplasm Lymphoplasmacytic Lymphoma Bone marrow examination stomatognathic diseases Leukemia medicine.anatomical_structure hemic and lymphatic diseases medicine Bone marrow business |
| Zdroj: | Practical Lymph Node and Bone Marrow Pathology ISBN: 9783030321888 |
| DOI: | 10.1007/978-3-030-32189-5_30 |
| Popis: | A bone marrow biopsy sometimes demonstrates two hematolymphoid neoplasms. In a majority of these cases, a second neoplasm is discovered unexpectedly when examining the marrow for a known or suspected hematolymphoid neoplasm. There are several possible combinations of neoplastic components, but in practice, many cases show a myeloid neoplasm along with a nonmyeloid neoplasm such as plasma cell neoplasm (PCN), chronic lymphocytic leukemia (CLL), other small mature B-cell leukemia/lymphoma, T-cell large granular lymphocytic leukemia (T-LGL), or other T-cell lymphomas. The myeloid neoplasm, usually myelodysplastic syndrome, may occur as a consequence of therapy given for the lymphoid neoplasm, and such cases are covered in Chapter 25. In addition, two different nonmyeloid neoplasms can be seen together, including PCN with CLL, PCN with lymphoplasmacytic lymphoma, CLL with T-LGL, CLL with B-lymphoblastic leukemia, etc. Diagnosis of these concomitant hematolymphoid neoplasms is challenging in that one neoplastic component can potentially mask the other in the bone marrow examination. Here, we highlight the diagnostic approach to correctly identify more than one neoplastic components by using ancillary test on the marrow as well as other laboratory studies, discuss potential etiologies of the concurrency, and emphasize the clinical significance of the phenomenon for treatment and prognosis. Bone marrow involvement by solid tumors, with or without concurrent hematolymphoid neoplasm, is discussed in Chapter 28. |
| Databáze: | OpenAIRE |
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