Size-dependent differences in mitochondrial volume density in phrenic motor neurons

Autor:	Matthew J. Fogarty, Sabhya Rana, Carlos B. Mantilla, Gary C. Sieck
Rok vydání:	2023
Předmět:	Physiology Physiology (medical)
Zdroj:	Journal of Applied Physiology. 134:1332-1340
ISSN:	1522-1601 8750-7587
DOI:	10.1152/japplphysiol.00021.2023
Popis:	Type S and FR motor units, comprising smaller phrenic motor neurons (PhMNs) are regularly activated to perform indefatigable ventilatory requirements. By contrast, type FF motor units, comprising larger PhMNs, are infrequently activated to perform expulsive straining and airway defense maneuvers. This difference in activation history is mirrored in the mitochondrial volume density (MVD), with smaller PhMNs having higher MVD than larger PhMNs. In proximal dendrites, this trend was reversed, with larger PhMNs having higher MVD than smaller PhMNs, likely due to the maintenance requirements for the larger dendritic arbor of FF PhMNs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43798ffe4e3bb8658d0c483996529a43 https://doi.org/10.1152/japplphysiol.00021.2023 Zobrazit plný text záznamu