Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study
| Autor: | Ming Hu, Huan-Zhong Shi, Juan Du, Ming Li, Guang Yun Guo, Wen Wang, Rong Hui Du, Qi Zhu, Peng Peng, Cheng Qing Yang, Tan Ze Cao, Li Rong Liang, Chun Lan Zheng, Xu Yan Li |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Univariate Case-control study 030204 cardiovascular system & hematology Logistic regression medicine.disease medicine.disease_cause Comorbidity 03 medical and health sciences Pneumonia 0302 clinical medicine Internal medicine Cohort medicine 030212 general & internal medicine business Prospective cohort study Coronavirus |
| Zdroj: | European Respiratory Journal. 55:2000524 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/13993003.00524-2020 |
| Popis: | The aim of this study was to identify factors associated with the death of patients with COVID-19 pneumonia caused by the novel coronavirus SARS-CoV-2.All clinical and laboratory parameters were collected prospectively from a cohort of patients with COVID-19 pneumonia who were hospitalised to Wuhan Pulmonary Hospital (Wuhan City, Hubei Province, China) between 25 December 2019 and 7 February 2020. Univariate and multivariate logistic regression was performed to investigate the relationship between each variable and the risk of death of COVID-19 pneumonia patients.In total, 179 patients with COVID-19 pneumonia (97 male and 82 female) were included in the present prospective study, of whom 21 died. Univariate and multivariate logistic regression analysis revealed that age ≥65 years (OR 3.765, 95% CI 1.146‒17.394; p=0.023), pre-existing concurrent cardiovascular or cerebrovascular diseases (OR 2.464, 95% CI 0.755‒8.044; p=0.007), CD3+CD8+ T-cells ≤75 cells·μL−1 (OR 3.982, 95% CI 1.132‒14.006; p−1 (OR 4.077, 95% CI 1.166‒14.253; p+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1 remained as predictors for high mortality from COVID-19 pneumonia.We identified four risk factors: age ≥65 years, pre-existing concurrent cardiovascular or cerebrovascular diseases, CD3+CD8+ T-cells ≤75 cells·μL−1 and cardiac troponin I ≥0.05 ng·mL−1. The latter two factors, especially, were predictors for mortality of COVID-19 pneumonia patients. |
| Databáze: | OpenAIRE |
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