Molecular recognition studies with a simple dipyrrinone

Autor:	Vincent J. Catalano, Michael T. Huggins, Chris Musto, Lyndsay Munro
Rok vydání:	2007
Předmět:	Hydrogen bond Chemistry Chemical shift Organic Chemistry Single step Atmospheric temperature range Biochemistry Combinatorial chemistry Molecular recognition Hydrogen Sulfate Drug Discovery Organic chemistry Moiety Anion binding
Zdroj:	Tetrahedron. 63:12994-12999
ISSN:	0040-4020
DOI:	10.1016/j.tet.2007.10.033
Popis:	We present our investigations of 2-ethyl-3-methyl-(10H)-dipyrrin-1-one, its self-association, and anion binding properties. This receptor is easily accessible in a facile single step synthesis with a straightforward workup. An examination of the concentration dependence of the dipyrrinone NH chemical shifts in CDCl3 and (CDCl2)2 over the temperature range from −20 °C to 100 °C determined the self-association constant to be 3850 M−1. Molecular recognition studies have shown that it has a preference for guests with an OH moiety, such as hydrogen sulfate (HSO4−) and carboxylic acids (RCO2H).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4361074a33c35464d67e2893641c96c4 https://doi.org/10.1016/j.tet.2007.10.033 Zobrazit plný text záznamu Full Text from ScienceDirect