TCDD inhibits murine thymocyte and B lymphocyte maturation
| Autor: | Gary J. Rosenthal, Michael I. Luster, J.J. Heindel, George C. Clark, B L Blaylock, C E Comment, S. D. Holladay, Dori R. Germolec |
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| Rok vydání: | 1992 |
| Předmět: |
Environmental Engineering
Perinatal Exposure Health Toxicology and Mutagenesis Cellular differentiation Lymphocyte Public Health Environmental and Occupational Health General Medicine General Chemistry Biology Pollution In vitro stomatognathic diseases Thymocyte medicine.anatomical_structure Immunity Immunopathology Toxicity Immunology medicine Environmental Chemistry heterocyclic compounds |
| Zdroj: | Chemosphere. 25:115-118 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(92)90493-b |
| Popis: | Immunotoxicity is a common occurrence in experimental animals following exposure to TCDD. In addition to thymic atrophy, immunotoxicity is characterized by suppression of antibody responses in adult mice and suppression of cell-mediated immunity following perinatal exposure. Studies in our laboratory have investigated the effects of perinatal TCDD exposure on thymocyte maturation and differentiation. In addition, we have examined TCDD-induced effects on B lymphocyte maturation and differentiation in vitro |
| Databáze: | OpenAIRE |
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