Phytochemical and Antitrypanosomal Studies of Different Solvents Extracts of Boswellia dalzielii

Autor:	Lazarus Md Yusufu, Sunday E. Atawodi, Uche Samuel Ndidi, Joy Joseph-Idrisu
Rok vydání:	2011
Předmět:	Stem bark Chloroform biology Traditional medicine Trypanosoma brucei biology.organism_classification complex mixtures Terpene chemistry.chemical_compound Biochemistry chemistry Phytochemical Boswellia dalzielii In vivo visual_art parasitic diseases visual_art.visual_art_medium Bark
Zdroj:	International Journal of Biology. 3
ISSN:	1916-968X 1916-9671
DOI:	10.5539/ijb.v3n2p179
Popis:	Solvent extracts of the various parts of Boswellia dalzielii (leaves, stem bark and root bark) were screened in vitro and in vivo for antitrypanosomal activity against Trypanosoma brucei brucei. Methanolic extract of the leaves, stem bark and root bark of Boswellia dalzielii at 20 mg/ml caused motility to cease after 35, 20 and 20 minutes, respectively while at 10 mg/ml, motility ceased at 50, 30 and 20 minutes respectively. Chloroform extract of root bark of the plant caused motility to cease after 40 minutes at concentration of 20 mg/ml. In vivo activity of methanol extract of the plant on T. brucei brucei infected mice showed consistent parasitemic suppressions at 300 mg/kg with methanolic extract of the leaves displaying highest activity. Reagent-based chemical analysis conducted on the extract revealed the presence of saponins, alkaloids, flavonoids, tannins, resins, steroids and triterpenes. These findings suggest that methanolic extract of Boswellia dalzielii leaves is more effective than other parts of the plant, and hence deserve further evaluation in the therapy of trypanosomiasis.
Databáze:	OpenAIRE
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