Synthesis, Anticholinesterase, and Antibacterial Activity of N-Aroyl-a-Aminoacrylic Acid Dialkylaminoalkylamides

Autor:	V. O. Topuzyan, R. V. Paronikyan, Z. G. Alebyan
Rok vydání:	2015
Předmět:	Pharmacology Erythrocyte acetylcholinesterase biology Aché language.human_language chemistry.chemical_compound Hydrolysis chemistry Drug Discovery Acetylthiocholine biology.protein language Ammonium Antibacterial activity Butyrylcholinesterase Cholinesterase Nuclear chemistry
Zdroj:	Pharmaceutical Chemistry Journal. 49:304-308
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-015-1274-0
Popis:	N-Aroyl-α-aminoacrylic acid 2-(dialkylamino)alkylamides and their quaternary ammonium salts were synthesized and their physicochemical properties were determined. Results obtained from studies of their interactions with human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) are presented. IC50 values (concentrations producing 50% inhibition of the rate of cholinesterase hydrolysis of 0.1 mM acetylthiocholine) were determined for all the compounds synthesized. The results show that all the compounds synthesized had anticholinesterase properties, mainly specific in relation to BChE. Data on the antibacterial properties of the synthesized compounds are also presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::435372b000eb83683639946377ba64aa https://doi.org/10.1007/s11094-015-1274-0 Zobrazit plný text záznamu Plný text ve formátu PDF