Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
| Autor: | Jonathon C. Arnold, Charlotte Klein, Jarrah R. Spencer, Alexander Wong, Thanh Huynh, Emily A Karanges, Leonora E. Long, Nathan Gunasekaran, Tim Karl, Adena S. Spiro, Xu-Feng Huang, Kelly Liu, Iain S. McGregor |
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| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
biology business.industry organic chemicals medicine.medical_treatment biology.organism_classification digestive system digestive system diseases Dose–response relationship surgical procedures operative Pharmacokinetics mental disorders medicine Cannabinoid Cannabis Dronabinol Δ9-tetrahydrocannabinol business Tetrahydrocannabinol Cannabidiol medicine.drug |
| Zdroj: | Psychopharmacology. 218:443-457 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/s00213-011-2342-0 |
| Popis: | Rationale The interactions between Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during chronic treatment, and at equivalent doses, are not well characterised in animal models. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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